Shuri almost manages to extract the Mind Stone from Vision but Thanos is already there, wreaking havoc. Thanos’ army attacks Wakanda where the rest of the Avengers put up a brave but weakened fight.

Strange offers up the Time Stone in exchange to spare Stark’s life. But Quill realizes that Gamora is dead and breaks the power hold of the group in fury, which severely injures Stark. They plan to subdue him despite Thanos’ justification, and are succeeded when Nebula overpowers Thanos.

Stark and Parker save Strange and meet the rest on Titan where using the Time Stone, Strange deduces only one future that guarantees the Avengers’ win. Nebula escapes Thanos’ captivity and dispatches a message for the rest of the Guardians to meet on Titan. Rogers, Romanoff and Sam Wilson save Wanda and Vision, and take them to the Avengers compound to debate on how to keep Thanos from stealing the stone, with or without killing Vision. The rest of Thanos’ lieutenants ambush the Avengers in Edinburgh, to steal the Mind Stone from Vision’s forehead. He kidnaps Gamora and sacrifices her to the Soul Stone's keeper, Red Skull, and acquires it. The rest of the crew try to stop Thanos from taking the Reality Stone, but they are too late. Thor manages a distress call and goes to Nidavellir to create a powerful weapon called Stormbreaker. Thanos’ troop is after the Reality Stone being guarded in Knowhere. Stark and Parker sneak onto Maw’s spaceship and Wong stays to guard the Sanctum.

They are unable to steal it, and so they capture Strange instead. They recruit Stark when Thanos’ lieutenants arrive to steal the Time Stone, which draws Peter Parker to them. Hulk, reverted to his form of Bruce Banner in Sanctum Sanctorum, warns Strange and Wong about Thanos’ plan to destroy half of all life on the planet. Thanos subdues and weakens them, kills Loki, kidnaps Nebula, and destroys the spaceship while stealing the Space Stone. His lieutenants and him intercept a spaceship that carried the survivors of the Asgard destruction. Thanos, already in possession of the Power Stone, is after the remaining five infinity stones.

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